Semaglutide
What is Semaglutide?
Semaglutide is a medication that mimics a natural hormone in your body called GLP-1 (glucagon-like peptide-1). It was originally developed to help people with type 2 diabetes manage their blood sugar, but it’s now widely used for weight loss and metabolic support—even in people without diabetes.
Average weight loss: ~15% body weight
Uses: Weight loss, blood sugar regulation (T2D), and may support inflammation reduction, PCOS management, and metabolic syndrome.
Benefits: Appetite suppression, delayed gastric emptying, improved glycemic control, reduced risk of heart disease, inflammation reduction.
Risks/Side Effects: Nausea, vomiting, constipation
Men-Specific Uses: Supports fat loss with preservation of lean muscle, helps reduce visceral fat linked to metabolic syndrome.
Women-Specific Uses: May regulate appetite swings tied to hormonal cycles, supports fat loss with preservation of lean muscle, helps to reduce symptoms of perimenopause & menopause.
Semaglutide Simplified:
Semaglutide helps you feel full faster and stay full longer, so you eat less. It also helps keep your blood sugar steady. Many people lose up to 15% of their body weight using this medication.
Tirzepatide
What is Tirzepatide?
Tirzepatide is a cutting-edge medication that targets two powerful metabolic pathways to support weight loss, blood sugar control, and overall metabolic health. It’s known as a dual GIP/GLP-1 receptor agonist—meaning it mimics two natural hormones involved in appetite regulation and insulin sensitivity.
Average weight loss: 20%-22%+ body weight
Uses: Weight loss, blood sugar control
Benefits: More potent appetite suppression vs. semaglutide, may improve insulin sensitivity, improves overall metabolic health, and may support inflammation reduction, PCOS management, and metabolic syndrome.
Risks/Side Effects: Similar to semaglutide
Men-Specific Uses: Enhances metabolic flexibility, supports strength training by reducing body fat, improves metabolic health.
Women-Specific Uses: Rapid fat loss in stubborn areas, can assist in weight loss, resistant to diet/exercise alone due to hormones, helps to reduce symptoms of perimenopause & menopause, imrpoves metabolic health.
Tirzepatide Simplified:
Tirzepatide works on two hunger hormones, making it even more powerful than Semaglutide for weight loss—some people lose over 22% of their body weight. Great for people who’ve tried other options but want faster results.
Retatrutide
What is Retatrutide?
Retatrutide is a next-generation weight loss medication that targets three metabolic receptors—GLP-1, GIP, and glucagon—making it one of the most powerful peptide-based therapies currently in development.
It’s sometimes referred to as the "triple agonist" because of its multi-receptor activity, giving it a broader impact on appetite, metabolism, and fat burning than other medications like Semaglutide or Tirzepatide.
Average weight loss: 24%+ body weight
Uses: Next-gen weight loss treatment for people focused on fat loss specifically
Benefits: Multi-receptor activity for superior fat loss, increased resting energy expenditure
Risks/Side Effects: GI upset, potential increase in heart rate, not FDA-approved yet
Men-Specific Uses: Aggressive fat loss with metabolic boost
Women-Specific Uses: Helps target hormonal weight retention zones
Retatrutide Simplified:
This is the newest and strongest of the weight-loss peptides. It works in three ways to help burn fat and boost energy.
Beyond Weight Loss: Microdosing GLP-1s
Most people think of GLP-1 medications as “weight loss shots,” but the science tells a bigger story—especially when these peptides are microdosed.
Wellness Benefits of Microdosed GLP-1 Peptides
✔ Supports adrenal recovery: Helps reduce cortisol spikes and stabilize energy levels.
✔ Improves histamine tolerance: Lowers mast cell activation and promotes a healthy microbiome.
✔ Calms neuroinflammation: Modulates microglial activity for clearer, sharper thinking.
✔ Reduces anxiety: Stimulates the vagus nerve and balances the HPA axis for improved stress resilience.
✔ Boosts mitochondrial health: Enhances AMPK activity and cellular energy production without overstimulation.
✔ Raises BDNF: Supports brain function, focus, and neuroplasticity (your brain’s ability to adapt and grow).
✔ Regulates estrogen metabolism: Supports liver detoxification of estrogen metabolites.
✔ Supports methylation: Helps lower homocysteine and reduce methylation-related stress in the body.
✔ Improves thyroid conversion: Enhances T4 to T3 conversion while reducing reverse T3, supporting thyroid health.
✔ Heals gut lining: Reduces inflammation and improves the integrity of the gut barrier.
✔ Enhances nutrient absorption: Slows digestive transit to support better uptake of essential nutrients.
✔ Modulates dopamine: Helps reduce food cravings and reward-seeking behaviors.
✔ Lowers blood pressure: Improves nitric oxide production and endothelial (blood vessel) function.
✔ Reduces autoimmunity triggers: Lowers inflammation and decreases gut permeability.
✔ Supports detox pathways: Reduces the metabolic burden on the liver, helping your detox systems work more efficiently.
What is Microdosing?
Microdosing means using a low, controlled dose of a compound to support your body’s natural balance—not to suppress it. Instead of pushing the body into an extreme state (like rapid appetite suppression), microdosing GLP-1 peptides helps fine-tune your biology for energy, hormone balance, inflammation support, and overall metabolic wellness.
The goal? Optimize how your body feels and functions—not just change the number on the scale.
How Does Microdosing Work?
Your body already produces GLP-1 naturally in your gut to help regulate blood sugar, insulin, appetite, and energy balance. But in times of stress, aging, or chronic inflammation, your natural GLP-1 production and sensitivity may decline.
Microdosing prescription-grade GLP-1 peptides helps:
✔ Restore your body’s natural signaling pathways
✔ Improve cellular energy without overstimulation
✔ Support the brain-gut-hormone connection for total-body wellness
Unlike higher doses used for diabetes or obesity, microdosing is designed for metabolic optimization, hormone balance, and inflammation support.
Who Is This For?
Microdosed GLP-1 therapy may benefit:
✔ Busy professionals & parents experiencing burnout, brain fog, and energy crashes
✔ Perimenopausal & postmenopausal women looking for hormone balance and inflammation support
✔ People with autoimmune or gut health struggles seeking natural ways to calm inflammation and heal the gut lining
✔ Fitness enthusiasts & athletes wanting better mitochondrial health, thyroid function, and recovery
✔ Anyone looking to optimize how their body feels—not just what the scale says