Semaglutide
What is Semaglutide?
Semaglutide is a medication that mimics a natural hormone in your body called GLP-1 (glucagon-like peptide-1). It was originally developed to help people with type 2 diabetes manage their blood sugar, but it’s now widely used for weight loss and metabolic support—even in people without diabetes.
Average weight loss: ~15% body weight
Uses: Weight loss, blood sugar regulation (T2D), and may support inflammation reduction, PCOS management, and metabolic syndrome.
Benefits: Appetite suppression, delayed gastric emptying, improved glycemic control, reduced risk of heart disease, inflammation reduction.
Risks/Side Effects: Nausea, vomiting, constipation
Men-Specific Uses: Supports fat loss with preservation of lean muscle, helps reduce visceral fat linked to metabolic syndrome.
Women-Specific Uses: May regulate appetite swings tied to hormonal cycles, supports fat loss with preservation of lean muscle, helps to reduce symptoms of perimenopause & menopause.
Semaglutide Simplified:
Semaglutide helps you feel full faster and stay full longer, so you eat less. It also helps keep your blood sugar steady. Many people lose up to 15% of their body weight using this medication.
Tirzepatide
What is Tirzepatide?
Tirzepatide is a cutting-edge medication that targets two powerful metabolic pathways to support weight loss, blood sugar control, and overall metabolic health. It’s known as a dual GIP/GLP-1 receptor agonist—meaning it mimics two natural hormones involved in appetite regulation and insulin sensitivity.
Average weight loss: 20%-22%+ body weight
Uses: Weight loss, blood sugar control
Benefits: More potent appetite suppression vs. semaglutide, may improve insulin sensitivity, improves overall metabolic health, and may support inflammation reduction, PCOS management, and metabolic syndrome.
Risks/Side Effects: Similar to semaglutide
Men-Specific Uses: Enhances metabolic flexibility, supports strength training by reducing body fat, improves metabolic health.
Women-Specific Uses: Rapid fat loss in stubborn areas, can assist in weight loss, resistant to diet/exercise alone due to hormones, helps to reduce symptoms of perimenopause & menopause, imrpoves metabolic health.
Tirzepatide Simplified:
Tirzepatide works on two hunger hormones, making it even more powerful than Semaglutide for weight loss—some people lose over 22% of their body weight. Great for people who’ve tried other options but want faster results.
Retatrutide
What is Retatrutide?
Retatrutide is a next-generation weight loss medication that targets three metabolic receptors—GLP-1, GIP, and glucagon—making it one of the most powerful peptide-based therapies currently in development.
It’s sometimes referred to as the "triple agonist" because of its multi-receptor activity, giving it a broader impact on appetite, metabolism, and fat burning than other medications like Semaglutide or Tirzepatide.
Average weight loss: 24%+ body weight
Uses: Next-gen weight loss treatment for people focused on fat loss specifically
Benefits: Multi-receptor activity for superior fat loss, increased resting energy expenditure
Risks/Side Effects: GI upset, potential increase in heart rate, not FDA-approved yet
Men-Specific Uses: Aggressive fat loss with metabolic boost
Women-Specific Uses: Helps target hormonal weight retention zones
Retatrutide Simplified:
This is the newest and strongest of the weight-loss peptides. It works in three ways to help burn fat and boost energy.